1. Scrooge McDuck (Duck Tales)
   Bender (Futurama)
2. Edd (Ed, Edd n Eddy)
   Max Goof (Goof Troop)

Scrooge McDuck is one of the main characters that appears in "Duck Tales." Scrooge McDuck is best known for being a wealthy business magnate and the uncle of Donald Duck.

1. Eric Cartman (South Park)
   Pinky (Pinky and the Brain)
2. Batman (Batman: The Animated Series)
   Yakko (Animaniacs)

Batman is the central character that appears in "Batman: The Animated Series." Batman is best known for being a superhero that fights crime in the dangerous city of Gotham.

1. Kenny McCormick (South Park)
   Homer Simpson (The Simpsons)
2. SpongeBob SquarePants (SpongeBob SquarePants)
   Beavis (Beavis and Butt-Head)

Beavis is one of the main characters that appears in "Beavis and Butt-Head." Beavis is best known for being the best friend of the other title character, Butt-Head. He is voiced by the series creator, Mike Judge.

1. NegaDuck (Darkwing Duck)
   Wakko (Animaniacs)
2. Dexter (Dexter’s Laboratory)
   Krusty the Clown (The Simpsons)

Wakko is one of the main characters that appears in "Animaniacs." Wakko Warner is best known for being the middle child and also the wackiest of the Warner siblings (as his name suggests).

1. Dot (Animaniacs)
   Stewie Griffin (Family Guy)
2. Max Goof (Goof Troop)
   Goliath (Gargoyles)

Goliath is one of the main characters that appears in "Gargoyles." Goliath is best known for being strong, intelligent and the leader of the Manhattan Clan.

1. NegaDuck (Darkwing Duck)
   Harley Quinn (Batman: The Animated Series)
2. Eric Cartman (South Park)
   Hank Hill (King of the Hill)

Harley Quinn is one of the main characters that appears in "Batman: The Animated Series." Harley Quinn is best known for being an original character created for the show and closest accomplice of the Joker.

1. Rocko (Rocko’s Modern Life)
   Kenny McCormick (South Park)
2. Kyle Broflovski (South Park)
   Arnold (Hey Arnold!)

Rocko is the title character of "Rocko’s Modern Life." Rocko is best known for being a wallaby that emigrates from Australia to America and goes to high school there.

1. Buster Bunny (Tiny Toon Adventures)
   Tommy Pickles (Rugrats)
2. The Brain (Pinky and the Brain)
   Homer Simpson (The Simpsons)

Tommy Pickles is one of the main characters that appears in "Rugrats." Tommy Pickles is best known for being the kind and brave de facto leader of his play group.

1. Dot (Animaniacs)
   Krusty the Clown (The Simpsons)
2. Yakko (Animaniacs)
   Leela (Futurama)

Leela is one of the main characters that appears in "Futurama." Leela is best known for being strong-willed and is arguably the most competent person working at Planet Express.

1. Scrooge McDuck (Duck Tales)
   Bart Simpson (The Simpsons)
2. Lisa Simpson (The Simpsons)
   Bender (Futurama)

Bart Simpson is one of the main characters that appears in "The Simpsons." Bart Simpson is best known for being rebellious and mischievous, as well as the eldest child and only son of Homer and Marge.

1. Johnny Bravo (Johnny Bravo)
   Batman (Batman: The Animated Series)
2. Stan Marsh (South Park)
   The Brain (Pinky and the Brain)

Johnny Bravo is the titular character of the show of the same name, "Johnny Bravo." He is best known for being a muscular womanizer who is almost always unsuccessful in his interactions with women.

1. Hank Hill (King of the Hill)
   Tommy Pickles (Rugrats)
2. Dee Dee (Dexter’s Laboratory)
   Butt-Head (Beavis and Butt-Head)

Dee Dee is one of the main characters that appears in "Dexter’s Laboratory." Dee Dee is best known for being the older sister of Dexter who oftentimes proves to be an annoyance to her younger brother.

1. Kyle Broflovski (South Park)
   Sonic the Hedgehog (Sonic the Hedgehog)
2. Fry (Futurama)
   Plucky Duck (Tiny Toon Adventures)

Sonic the Hedgehog is the titular character of the show of the same name, "Sonic the Hedgehog." Sonic is best known for being a freedom fighter that is fighting to free the world from Dr. Robotnik.

1. Wakko (Animaniacs)
   SpongeBob SquarePants (SpongeBob SquarePants)
2. Bubbles (The Powerpuff Girls)
   Stewie Griffin (Family Guy)

Bubbles is one of the main characters that appears in "The Powerpuff Girls." Bubbles is best known for being the sister of Blossom and Buttercup, as well as a hero in the city of Townsville.

1. Goliath (Gargoyles)
   Bart Simpson (The Simpsons)
2. Butt-Head (Beavis and Butt-Head)
   Chuckie Finster (Rugrats)

Chuckie Finster is one of the main characters that appears in "Rugrats." Chuckie is known for being the best friend of Tommy, and he is also a scaredy-cat.

1. Tom Cat (Tom and Jerry)
   Sonic the Hedgehog (Sonic the Hedgehog)
2. Fry (Futurama)
   Harley Quinn (Batman: The Animated Series)

Fry is the protagonist of "Futurama." Fry was accidentally cryogenically frozen at the end of 1999 and then revived in the year 2999; he works as a delivery boy for Planet Express.

1. Butt-Head (Beavis and Butt-Head)
   Rocko (Rocko’s Modern Life)
2. Dee Dee (Dexter’s Laboratory)
   Chuckie Finster (Rugrats)

Butt-Head is one of the main characters that appears in "Beavis and Butt-Head." Butt-Head is the best friend of the other title character, Beavis.

1. Pinky (Pinky and the Brain)
   Johnny Bravo (Johnny Bravo)
2. Beavis (Beavis and Butt-Head)
   Stan Marsh (South Park)

Stan Marsh appears in "South Park." Stan Marsh is one of the main characters of the show, along with Eric Cartman, Kyle Broflovski and Kenny McCormick.

1. Lisa Simpson (The Simpsons)
   Leela (Futurama)
2. Bubbles (The Powerpuff Girls)
   Edd (Ed, Edd n Eddy)

Lisa Simpson is one of the main characters that appears in "The SImpsons." Lisa is best known for being the most intelligent member of the Simpson family and the middle child.

1. Goliath (Gargoyles)
   Max Goof (Goof Troop)
2. Lisa Simpson (The Simpsons)
   Edd (Ed, Edd n Eddy)

Edd is one of the main characters that appears in "Ed, Edd n Eddy." Edd is best known for being the most intelligent member of the group, as well as also a neat freak and inventor.

1. Harley Quinn (Batman: The Animated Series)
   Pinky (Pinky and the Brain)
2. Eric Cartman (South Park)
   Stan Marsh (South Park)

Pinky is one of the main characters that appears in "Pinky and the Brain." Pinky is best known for being the good-natured half of the duo and also appears to be a bit dimwitted.

1. Rocko (Rocko’s Modern Life)
   Kenny McCormick (South Park)
2. Tommy Pickles (Rugrats)
   SpongeBob SquarePants (SpongeBob SquarePants)

SpongeBob SquarePants is the titular character of the show of the same name, "SpongeBob SquarePants." Spongebob is best known for being the good-natured and naïve fry cook who works at the Krusty Krab.

1. Beavis (Beavis and Butt-Head)
   Tom Cat (Tom and Jerry)
2. Buster Bunny (Tiny Toon Adventures)
   Fry (Futurama)

Tom Cat is one of the main characters that appears in "Tom and Jerry." Tom is best known for being the longstanding rival of the other title character, Jerry.

1. Dexter (Dexter’s Laboratory)
   Leela (Futurama)
2. Krusty the Clown (The Simpsons)
   Chuckie Finster (Rugrats)

Dexter is the titular character of "Dexter’s Laboratory." Dexter is best known for being a boy-genius who has a secret laboratory where he creates and houses his inventions.

1. Scrooge McDuck (Duck Tales)
   Dot (Animaniacs)
2. Stewie Griffin (Family Guy)
   Bubbles (The Powerpuff Girls)

Stewie Griffin is one of the main characters that appears in "Family Guy." Stewie is best known for being an intelligent infant and the youngest child of Peter and Lois.

1. Batman (Batman: The Animated Series)
   Yakko (Animaniacs)
2. Kyle Broflovski (South Park)
   Sonic the Hedgehog (Sonic the Hedgehog)

Kyle Broflovski is one of the main characters that appears in "South Park." Kyle is best known for being one of the main characters of the show, along with Eric Cartman, Stan Marsh, and Kenny McCormick.

1. Dexter (Dexter’s Laboratory)
   Hank Hill (King of the Hill)
2. Homer Simpson (The Simpsons)
   Dee Dee (Dexter’s Laboratory)

Hank Hill is one of the main characters that appears in "King of the Hill." Hank is best known for being the conservative assistant manager of Strickland Propane. He is deeply passionate about propane and propane accessories.

1. The Brain (Pinky and the Brain)
   Plucky Duck (Tiny Toon Adventures)
2. NegaDuck (Darkwing Duck)
   Johnny Bravo (Johnny Bravo)

The Brain is one of the main characters that appears in "Pinky and the Brain." He is best known for being the more nefarious one of the duo who is always trying to take over the world.

1. Bart Simpson (The Simpsons)
   Arnold (Hey Arnold!)
2. Bender (Futurama)
   Wakko (Animaniacs)

Bender is one of the main characters that appears in "Futurama." Bender (also known as Bending Unit 22, unit number 1,729, serial number 2716057) is best known for being the alcoholic and chain-smoking robot who is the assistant manager of sales at Planet Express.

1. Lisa Simpson (The Simpsons)
   Yakko (Animaniacs)
2. Kyle Broflovski (South Park)
   Leela (Futurama)

Yakko is one of the main characters that appears in "Animaniacs." Yakko Warner is best known for being the oldest of the Warner siblings and also the most talkative one as well.

1. Stan Marsh (South Park)
   The Brain (Pinky and the Brain)
2. Beavis (Beavis and Butt-Head)
   Homer Simpson (The Simpsons)

Homer Simpson is one of the main characters that appears in "The Simpsons." Homer is best known for being the dim-witted patriarch of the Simpson family and a safety inspector at the Springfield Nuclear Power Plant.

1. Rocko (Rocko’s Modern Life)
   Bender (Futurama)
2. Arnold (Hey Arnold!)
   Tommy Pickles (Rugrats)

Arnold is the titular character of the show that shares his name, "Hey Arnold!" Arnold is a fourth-grader who lives with his grandparents in the city.

1. Harley Quinn (Batman: The Animated Series)
   Hank Hill (King of the Hill)
2. Fry (Futurama)
   NegaDuck (Darkwing Duck)

NegaDuck is one of the main characters that appears in "Darkwing Duck." NegaDuck is best known for being the evil twin of the protagonist, Darkwing Duck, and the main antagonist of the series.

1. Chuckie Finster (Rugrats)
   Dot (Animaniacs)
2. Stewie Griffin (Family Guy)
   Goliath (Gargoyles)

Dot is one of the main characters that appears in "Animaniacs." Dot Warner is best known for being the only girl of the Warner siblings and the youngest one as well.

1. Wakko (Animaniacs)
   Butt-Head (Beavis and Butt-Head)
2. Bubbles (The Powerpuff Girls)
   Krusty the Clown (The Simpsons)

Krusty the Clown is one of the main characters that appears in "The Simpsons." Krusty is best known for being the cynical chain-smoking host of "The Itchy & Scratchy Show," Lisa and Bart’s favorite TV show.

1. Buster Bunny (Tiny Toon Adventures)
   Sonic the Hedgehog (Sonic the Hedgehog)
2. Plucky Duck (Tiny Toon Adventures)
   Tom Cat (Tom and Jerry)

Buster Bunny is one of the main characters that appears in "Tiny Toon Adventures." Buster Bunny is best known for being the central character of the series (similar to how Bugs Bunny is the central character of Looney Tunes.

1. Dee Dee (Dexter’s Laboratory)
   SpongeBob SquarePants (SpongeBob SquarePants)
2. Kenny McCormick (South Park)
   Dexter (Dexter’s Laboratory)

Kenny McCormick is one of the main characters that appears in "South Park." Kenny is best known for being one of the main characters of the show, along with Eric Cartman, Stan Marsh and Kyle Broflovski.

1. Eric Cartman (South Park)
   Johnny Bravo (Johnny Bravo)
2. Pinky (Pinky and the Brain)
   Batman (Batman: The Animated Series)

Eric Cartman appears in "South Park." Cartman is best known for being one of the main characters of the show, along with Kyle Broflovski, Stan Marsh and Kenny McCormick.

1. Scrooge McDuck (Duck Tales)
   Bart Simpson (The Simpsons)
2. Max Goof (Goof Troop)
   Edd (Ed, Edd n Eddy)

Max Goof is one of the main characters that appears in "Goof Troop." Max Goof is best known for being the son of the long-standing Disney character, Goofy.